Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA

Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA

Voltage-activated Ca2+ channels (VACCs) mediate Ca2+ influx to trigger action potential-evoked neurotransmitter release but the mechanism by which Ca2+ regulates spontaneous transmission is unclear. Here we show VACCs are the major physiological triggers for spontaneous release at murine neocortical...

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Main Authors: Williams, Courtney, Chen, Wenyan, Lee, Chia-Hsueh, Yaeger, Daniel, Vyleta, Nicholas P., Smith, Stephen M.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431448/
id pubmed-3431448
recordtype oai_dc
spelling pubmed-34314482013-03-01 Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA Williams, Courtney Chen, Wenyan Lee, Chia-Hsueh Yaeger, Daniel Vyleta, Nicholas P. Smith, Stephen M. Article Voltage-activated Ca2+ channels (VACCs) mediate Ca2+ influx to trigger action potential-evoked neurotransmitter release but the mechanism by which Ca2+ regulates spontaneous transmission is unclear. Here we show VACCs are the major physiological triggers for spontaneous release at murine neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we find that spontaneous fusion of a GABA-containing vesicle requires the activation of multiple tightly-coupled VACCs of variable type. 2012-07-29 2012-09 /pmc/articles/PMC3431448/ /pubmed/22842148 http://dx.doi.org/10.1038/nn.3162 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Williams, Courtney
Chen, Wenyan
Lee, Chia-Hsueh
Yaeger, Daniel
Vyleta, Nicholas P.
Smith, Stephen M.
spellingShingle Williams, Courtney
Chen, Wenyan
Lee, Chia-Hsueh
Yaeger, Daniel
Vyleta, Nicholas P.
Smith, Stephen M.
Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA
author_facet Williams, Courtney
Chen, Wenyan
Lee, Chia-Hsueh
Yaeger, Daniel
Vyleta, Nicholas P.
Smith, Stephen M.
author_sort Williams, Courtney
title Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA
title_short Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA
title_full Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA
title_fullStr Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA
title_full_unstemmed Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA
title_sort co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of gaba
description Voltage-activated Ca2+ channels (VACCs) mediate Ca2+ influx to trigger action potential-evoked neurotransmitter release but the mechanism by which Ca2+ regulates spontaneous transmission is unclear. Here we show VACCs are the major physiological triggers for spontaneous release at murine neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we find that spontaneous fusion of a GABA-containing vesicle requires the activation of multiple tightly-coupled VACCs of variable type.
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431448/
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