Co-activation of multiple tightly-coupled calcium channels triggers spontaneous release of GABA

Voltage-activated Ca2+ channels (VACCs) mediate Ca2+ influx to trigger action potential-evoked neurotransmitter release but the mechanism by which Ca2+ regulates spontaneous transmission is unclear. Here we show VACCs are the major physiological triggers for spontaneous release at murine neocortical...

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Bibliographic Details
Main Authors: Williams, Courtney, Chen, Wenyan, Lee, Chia-Hsueh, Yaeger, Daniel, Vyleta, Nicholas P., Smith, Stephen M.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431448/