Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer
Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are essential for the maturation of a wide spectrum of proteins involved in various biological processes. In the ER, these enzymes work in concert to trim peptides for presentation on MHC class I molecules. Loss of ERAPs function sub...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Molecular Diversity Preservation International (MDPI)
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430237/ |