17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells

Hsp90 chaperone has been identified as an attractive pharmacological target to combat cancer. However, some metastatic tumors either fail to respond to Hsp90 inhibition or show recovery necessitating irreversible therapeutic strategies. In response to this enforced senescence has been proposed as an...

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Bibliographic Details
Main Authors: Sarangi, Upasana, Paithankar, Khande Rao, Kumar, Jonnala Ujwal, Subramaniam, Vaidyanathan, Sreedhar, Amere Subbarao
Format: Online
Language:English
Published: Libertas Academica 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422084/