Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis

TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations...

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Main Authors:	Bellini, Marilanda Ferreira, Cadamuro, Aline Cristina Targa, Succi, Maysa, Proença, Marcela Alcântara, Silva, Ana Elizabete
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420349/

id	pubmed-3420349
recordtype	oai_dc
spelling	pubmed-34203492012-08-23 Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis Bellini, Marilanda Ferreira Cadamuro, Aline Cristina Targa Succi, Maysa Proença, Marcela Alcântara Silva, Ana Elizabete Review Article TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminates in the malignant transformation. Thus, this study highlights the participation of the main genetic alterations of the TP53 gene in esophageal and gastric carcinogenesis. Among these changes, high frequency of TP53 mutations, loss of heterozygosity (LOH), overexpression of the p53 protein, and consequently loss of p53 function, which would be early events in esophageal and gastric cancers, as well as an important biomarker of the prognosis and treatment response. Furthermore, Single Nucleotide Polymorphisms (SNPs) of TP53 have been implicated in the development and prognosis of several cancers, mainly TP53 codon 72 polymorphism whose role has been extensively studied in relation to susceptibility for esophageal and gastric cancer development. Hindawi Publishing Corporation 2012 2012-08-07 /pmc/articles/PMC3420349/ /pubmed/22919278 http://dx.doi.org/10.1155/2012/891961 Text en Copyright © 2012 Marilanda Ferreira Bellini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bellini, Marilanda Ferreira Cadamuro, Aline Cristina Targa Succi, Maysa Proença, Marcela Alcântara Silva, Ana Elizabete
spellingShingle	Bellini, Marilanda Ferreira Cadamuro, Aline Cristina Targa Succi, Maysa Proença, Marcela Alcântara Silva, Ana Elizabete Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
author_facet	Bellini, Marilanda Ferreira Cadamuro, Aline Cristina Targa Succi, Maysa Proença, Marcela Alcântara Silva, Ana Elizabete
author_sort	Bellini, Marilanda Ferreira
title	Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
title_short	Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
title_full	Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
title_fullStr	Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
title_full_unstemmed	Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
title_sort	alterations of the tp53 gene in gastric and esophageal carcinogenesis
description	TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminates in the malignant transformation. Thus, this study highlights the participation of the main genetic alterations of the TP53 gene in esophageal and gastric carcinogenesis. Among these changes, high frequency of TP53 mutations, loss of heterozygosity (LOH), overexpression of the p53 protein, and consequently loss of p53 function, which would be early events in esophageal and gastric cancers, as well as an important biomarker of the prognosis and treatment response. Furthermore, Single Nucleotide Polymorphisms (SNPs) of TP53 have been implicated in the development and prognosis of several cancers, mainly TP53 codon 72 polymorphism whose role has been extensively studied in relation to susceptibility for esophageal and gastric cancer development.
publisher	Hindawi Publishing Corporation
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420349/
_version_	1611550064868589568

Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis

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