Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

OCA2 is used as a model melanosome cargo protein to define primary sequence elements required for acidic dileucine–motif binding to adaptors AP-1 and AP-3. OCA2 must bind to AP-3 for melanosome localization. BLOC-1 is also required and thus can cooperate with either adaptor for cargo delivery to lys...

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Bibliographic Details
Main Authors: Sitaram, Anand, Dennis, Megan K., Chaudhuri, Rittik, De Jesus-Rojas, Wilfredo, Tenza, Danièle, Setty, Subba Rao Gangi, Wood, Christopher S., Sviderskaya, Elena V., Bennett, Dorothy C., Raposo, Graça, Bonifacino, Juan S., Marks, Michael S.
Format: Online
Language:English
Published: The American Society for Cell Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418312/

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