Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

OCA2 is used as a model melanosome cargo protein to define primary sequence elements required for acidic dileucine–motif binding to adaptors AP-1 and AP-3. OCA2 must bind to AP-3 for melanosome localization. BLOC-1 is also required and thus can cooperate with either adaptor for cargo delivery to lys...

Full description

Bibliographic Details
Main Authors:	Sitaram, Anand, Dennis, Megan K., Chaudhuri, Rittik, De Jesus-Rojas, Wilfredo, Tenza, Danièle, Setty, Subba Rao Gangi, Wood, Christopher S., Sviderskaya, Elena V., Bennett, Dorothy C., Raposo, Graça, Bonifacino, Juan S., Marks, Michael S.
Format:	Online
Language:	English
Published:	The American Society for Cell Biology 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418312/

id	pubmed-3418312
recordtype	oai_dc
spelling	pubmed-34183122012-10-30 Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes Sitaram, Anand Dennis, Megan K. Chaudhuri, Rittik De Jesus-Rojas, Wilfredo Tenza, Danièle Setty, Subba Rao Gangi Wood, Christopher S. Sviderskaya, Elena V. Bennett, Dorothy C. Raposo, Graça Bonifacino, Juan S. Marks, Michael S. Articles OCA2 is used as a model melanosome cargo protein to define primary sequence elements required for acidic dileucine–motif binding to adaptors AP-1 and AP-3. OCA2 must bind to AP-3 for melanosome localization. BLOC-1 is also required and thus can cooperate with either adaptor for cargo delivery to lysosome-related organelles. The American Society for Cell Biology 2012-08-15 /pmc/articles/PMC3418312/ /pubmed/22718909 http://dx.doi.org/10.1091/mbc.E11-06-0509 Text en © 2012 Sitaram et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sitaram, Anand Dennis, Megan K. Chaudhuri, Rittik De Jesus-Rojas, Wilfredo Tenza, Danièle Setty, Subba Rao Gangi Wood, Christopher S. Sviderskaya, Elena V. Bennett, Dorothy C. Raposo, Graça Bonifacino, Juan S. Marks, Michael S.
spellingShingle	Sitaram, Anand Dennis, Megan K. Chaudhuri, Rittik De Jesus-Rojas, Wilfredo Tenza, Danièle Setty, Subba Rao Gangi Wood, Christopher S. Sviderskaya, Elena V. Bennett, Dorothy C. Raposo, Graça Bonifacino, Juan S. Marks, Michael S. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
author_facet	Sitaram, Anand Dennis, Megan K. Chaudhuri, Rittik De Jesus-Rojas, Wilfredo Tenza, Danièle Setty, Subba Rao Gangi Wood, Christopher S. Sviderskaya, Elena V. Bennett, Dorothy C. Raposo, Graça Bonifacino, Juan S. Marks, Michael S.
author_sort	Sitaram, Anand
title	Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
title_short	Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
title_full	Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
title_fullStr	Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
title_full_unstemmed	Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
title_sort	differential recognition of a dileucine-based sorting signal by ap-1 and ap-3 reveals a requirement for both bloc-1 and ap-3 in delivery of oca2 to melanosomes
description	OCA2 is used as a model melanosome cargo protein to define primary sequence elements required for acidic dileucine–motif binding to adaptors AP-1 and AP-3. OCA2 must bind to AP-3 for melanosome localization. BLOC-1 is also required and thus can cooperate with either adaptor for cargo delivery to lysosome-related organelles.
publisher	The American Society for Cell Biology
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418312/
_version_	1611549541119557632

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

Similar Items