The gut microbiota regulates bone mass in mice

The gut microbiota regulates bone mass in mice

The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ-free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventiona...

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Main Authors: Sjögren, Klara, Engdahl, Cecilia, Henning, Petra, Lerner, Ulf H, Tremaroli, Valentina, Lagerquist, Marie K, Bäckhed, Fredrik, Ohlsson, Claes
Format: Online
Language:English
Published: Wiley Subscription Services, Inc., A Wiley Company 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415623/
id pubmed-3415623
recordtype oai_dc
spelling pubmed-34156232012-08-14 The gut microbiota regulates bone mass in mice Sjögren, Klara Engdahl, Cecilia Henning, Petra Lerner, Ulf H Tremaroli, Valentina Lagerquist, Marie K Bäckhed, Fredrik Ohlsson, Claes Original Articles The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ-free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventionally raised (CONV-R) mice. Colonization of GF mice with a normal gut microbiota normalizes bone mass. Furthermore, GF mice have decreased frequency of CD4+ T cells and CD11b+/GR 1 osteoclast precursor cells in bone marrow, which could be normalized by colonization. GF mice exhibited reduced expression of inflammatory cytokines in bone and bone marrow compared with CONV-R mice. In summary, the gut microbiota regulates bone mass in mice, and we provide evidence for a mechanism involving altered immune status in bone and thereby affected osteoclast-mediated bone resorption. Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis. © 2012 American Society for Bone and Mineral Research. Wiley Subscription Services, Inc., A Wiley Company 2012-06 /pmc/articles/PMC3415623/ /pubmed/22407806 http://dx.doi.org/10.1002/jbmr.1588 Text en Copyright © 2012 American Society for Bone and Mineral Research http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Sjögren, Klara
Engdahl, Cecilia
Henning, Petra
Lerner, Ulf H
Tremaroli, Valentina
Lagerquist, Marie K
Bäckhed, Fredrik
Ohlsson, Claes
spellingShingle Sjögren, Klara
Engdahl, Cecilia
Henning, Petra
Lerner, Ulf H
Tremaroli, Valentina
Lagerquist, Marie K
Bäckhed, Fredrik
Ohlsson, Claes
The gut microbiota regulates bone mass in mice
author_facet Sjögren, Klara
Engdahl, Cecilia
Henning, Petra
Lerner, Ulf H
Tremaroli, Valentina
Lagerquist, Marie K
Bäckhed, Fredrik
Ohlsson, Claes
author_sort Sjögren, Klara
title The gut microbiota regulates bone mass in mice
title_short The gut microbiota regulates bone mass in mice
title_full The gut microbiota regulates bone mass in mice
title_fullStr The gut microbiota regulates bone mass in mice
title_full_unstemmed The gut microbiota regulates bone mass in mice
title_sort gut microbiota regulates bone mass in mice
description The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ-free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventionally raised (CONV-R) mice. Colonization of GF mice with a normal gut microbiota normalizes bone mass. Furthermore, GF mice have decreased frequency of CD4+ T cells and CD11b+/GR 1 osteoclast precursor cells in bone marrow, which could be normalized by colonization. GF mice exhibited reduced expression of inflammatory cytokines in bone and bone marrow compared with CONV-R mice. In summary, the gut microbiota regulates bone mass in mice, and we provide evidence for a mechanism involving altered immune status in bone and thereby affected osteoclast-mediated bone resorption. Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis. © 2012 American Society for Bone and Mineral Research.
publisher Wiley Subscription Services, Inc., A Wiley Company
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415623/
_version_ 1611548864294158336

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