HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in Neurons

HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in Neurons

Major human pathologies are caused by nuclear replicative viruses establishing life-long latent infection in their host. During latency the genomes of these viruses are intimately interacting with the cell nucleus environment. A hallmark of herpes simplex virus type 1 (HSV-1) latency establishment i...

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Bibliographic Details
Main Authors: Catez, Frédéric, Picard, Christel, Held, Kathrin, Gross, Sylvain, Rousseau, Antoine, Theil, Diethilde, Sawtell, Nancy, Labetoulle, Marc, Lomonte, Patrick
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415458/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415458/

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