Peptidome Analysis of Cerebrospinal Fluid by LC-MALDI MS

We report on the analysis of endogenous peptides in cerebrospinal fluid (CSF) by mass spectrometry. A method was developed for preparation of peptide extracts from CSF. Analysis of the extracts by offline LC-MALDI MS resulted in the detection of 3,000–4,000 peptide-like features. Out of these, 730 p...

Full description

Bibliographic Details
Main Authors: Hölttä, Mikko, Zetterberg, Henrik, Mirgorodskaya, Ekaterina, Mattsson, Niklas, Blennow, Kaj, Gobom, Johan
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412831/