Warburg Effect’s Manifestation in Aggressive Pheochromocytomas and Paragangliomas: Insights from a Mouse Cell Model Applied to Human Tumor Tissue

Warburg Effect’s Manifestation in Aggressive Pheochromocytomas and Paragangliomas: Insights from a Mouse Cell Model Applied to Human Tumor Tissue

A glycolytic profile unifies a group of pheochromocytomas and paragangliomas (PHEOs/PGLs) with distinct underlying gene defects, including von Hippel-Lindau (VHL) and succinate dehydrogenase B (SDHB) mutations. Nevertheless, their tumor aggressiveness is distinct: PHEOs/PGLs metastasize rarely in VH...

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Main Authors: Fliedner, Stephanie M. J., Kaludercic, Nina, Jiang, Xiao-Sheng, Hansikova, Hana, Hajkova, Zuzana, Sladkova, Jana, Limpuangthip, Andrea, Backlund, Peter S., Wesley, Robert, Martiniova, Lucia, Jochmanova, Ivana, Lendvai, Nikoletta K., Breza, Jan, Yergey, Alfred L., Paolocci, Nazareno, Tischler, Arthur S., Zeman, Jiri, Porter, Forbes D., Lehnert, Hendrik, Pacak, Karel
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409208/

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