A1/Bfl-1 in leukocyte development and cell death
The function of the anti-apoptotic Bcl-2 family member Bcl2a1/Bfl-1/A1 is poorly understood due to the lack of appropriate loss-of-function mouse models and redundant effects with other Bcl-2 pro-survival proteins upon overexpression. Expression analysis of A1 suggests predominant roles in leukocyte...
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| Format: | Online |
| Language: | English |
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Academic Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405526/ |
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pubmed-34055262012-08-06 A1/Bfl-1 in leukocyte development and cell death Ottina, Eleonora Tischner, Denise Herold, Marco J. Villunger, Andreas Review Article The function of the anti-apoptotic Bcl-2 family member Bcl2a1/Bfl-1/A1 is poorly understood due to the lack of appropriate loss-of-function mouse models and redundant effects with other Bcl-2 pro-survival proteins upon overexpression. Expression analysis of A1 suggests predominant roles in leukocyte development, their survival upon viral or bacterial infection, as well as during allergic reactions. In addition, A1 has been implicated in autoimmunity and the pathology and therapy resistance of hematological as well as solid tumors that may aberrantly express this protein. In this review, we aim to summarize current knowledge on A1 biology, focusing on its role in the immune system and compare it to that of other pro-survival Bcl-2 proteins. Academic Press 2012-07-01 /pmc/articles/PMC3405526/ /pubmed/22342458 http://dx.doi.org/10.1016/j.yexcr.2012.01.021 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Ottina, Eleonora Tischner, Denise Herold, Marco J. Villunger, Andreas |
| spellingShingle |
Ottina, Eleonora Tischner, Denise Herold, Marco J. Villunger, Andreas A1/Bfl-1 in leukocyte development and cell death |
| author_facet |
Ottina, Eleonora Tischner, Denise Herold, Marco J. Villunger, Andreas |
| author_sort |
Ottina, Eleonora |
| title |
A1/Bfl-1 in leukocyte development and cell death |
| title_short |
A1/Bfl-1 in leukocyte development and cell death |
| title_full |
A1/Bfl-1 in leukocyte development and cell death |
| title_fullStr |
A1/Bfl-1 in leukocyte development and cell death |
| title_full_unstemmed |
A1/Bfl-1 in leukocyte development and cell death |
| title_sort |
a1/bfl-1 in leukocyte development and cell death |
| description |
The function of the anti-apoptotic Bcl-2 family member Bcl2a1/Bfl-1/A1 is poorly understood due to the lack of appropriate loss-of-function mouse models and redundant effects with other Bcl-2 pro-survival proteins upon overexpression. Expression analysis of A1 suggests predominant roles in leukocyte development, their survival upon viral or bacterial infection, as well as during allergic reactions. In addition, A1 has been implicated in autoimmunity and the pathology and therapy resistance of hematological as well as solid tumors that may aberrantly express this protein. In this review, we aim to summarize current knowledge on A1 biology, focusing on its role in the immune system and compare it to that of other pro-survival Bcl-2 proteins. |
| publisher |
Academic Press |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405526/ |
| _version_ |
1611545730523070464 |