Collective Epithelial and Mesenchymal Cell Migration During Gastrulation
Gastrulation, the process that puts the three major germlayers, the ectoderm, mesoderm and endoderm in their correct topological position in the developing embryo, is characterised by extensive highly organised collective cell migration of epithelial and mesenchymal cells. We discuss current knowled...
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| Format: | Online |
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Bentham Science Publishers
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394114/ |
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pubmed-33941142012-12-01 Collective Epithelial and Mesenchymal Cell Migration During Gastrulation Chuai, Manli Hughes, David Weijer, Cornelis J Article Gastrulation, the process that puts the three major germlayers, the ectoderm, mesoderm and endoderm in their correct topological position in the developing embryo, is characterised by extensive highly organised collective cell migration of epithelial and mesenchymal cells. We discuss current knowledge and insights in the mechanisms controlling these cell behaviours during gastrulation in the chick embryo. We discuss several ideas that have been proposed to explain the observed large scale vortex movements of epithelial cells in the epiblast during formation of the primitive streak. We review current insights in the control and execution of the epithelial to mesenchymal transition (EMT) underlying the formation of the hypoblast and the ingression of the mesendoderm cells through the streak. We discuss the mechanisms by which the mesendoderm cells move, the nature and dynamics of the signals that guide these movements, as well as the interplay between signalling and movement that result in tissue patterning and morphogenesis. We argue that instructive cell-cell signaling and directed chemotactic movement responses to these signals are instrumental in the execution of all phases of gastrulation. Bentham Science Publishers 2012-06 2012-06 /pmc/articles/PMC3394114/ /pubmed/23204916 http://dx.doi.org/10.2174/138920212800793357 Text en ©2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chuai, Manli Hughes, David Weijer, Cornelis J |
| spellingShingle |
Chuai, Manli Hughes, David Weijer, Cornelis J Collective Epithelial and Mesenchymal Cell Migration During Gastrulation |
| author_facet |
Chuai, Manli Hughes, David Weijer, Cornelis J |
| author_sort |
Chuai, Manli |
| title |
Collective Epithelial and Mesenchymal Cell Migration During Gastrulation |
| title_short |
Collective Epithelial and Mesenchymal Cell Migration During Gastrulation |
| title_full |
Collective Epithelial and Mesenchymal Cell Migration During Gastrulation |
| title_fullStr |
Collective Epithelial and Mesenchymal Cell Migration During Gastrulation |
| title_full_unstemmed |
Collective Epithelial and Mesenchymal Cell Migration During Gastrulation |
| title_sort |
collective epithelial and mesenchymal cell migration during gastrulation |
| description |
Gastrulation, the process that puts the three major germlayers, the ectoderm, mesoderm and endoderm in their correct topological position in the developing embryo, is characterised by extensive highly organised collective cell migration of epithelial and mesenchymal cells. We discuss current knowledge and insights in the mechanisms controlling these cell behaviours during gastrulation in the chick embryo. We discuss several ideas that have been proposed to explain the observed large scale vortex movements of epithelial cells in the epiblast during formation of the primitive streak. We review current insights in the control and execution of the epithelial to mesenchymal transition (EMT) underlying the formation of the hypoblast and the ingression of the mesendoderm cells through the streak. We discuss the mechanisms by which the mesendoderm cells move, the nature and dynamics of the signals that guide these movements, as well as the interplay between signalling and movement that result in tissue patterning and morphogenesis. We argue that instructive cell-cell signaling and directed chemotactic movement responses to these signals are instrumental in the execution of all phases of gastrulation. |
| publisher |
Bentham Science Publishers |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394114/ |
| _version_ |
1611542301280043008 |