Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage

Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage

ALKBH2 is a direct DNA repair dioxygenase guarding mammalian genome against N1-methyladenine, N3-methylcytosine, and 1,N6-ethenoadenine damage. A prerequisite for repair is to identify these lesions in the genome. Here we present crystal structures of ALKBH2 bound to different duplex DNAs. Together...

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Bibliographic Details
Main Authors: Yi, Chengqi, Chen, Baoen, Qi, Bo, Zhang, Wen, Jia, Guifang, Zhang, Liang, Li, Charles J., Dinner, Aaron R., Yang, Cai-Guang, He, Chuan
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392526/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392526/

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