Iron-Catalyzed Oxidation Intermediates Captured in a DNA Repair Dioxygenase
Mononuclear iron-containing oxygenases conduct a diverse variety of oxidation functions in biology1,2, including the oxidative demethylation of methylated nucleic acids and histones3,4. E. coli AlkB is the first such enzyme that was discovered to repair methylated nucleic acids (Fig. 1)5,6, which ar...
| Main Authors: | , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058853/ |