A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression. We previously reported that the translocation red...

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Bibliographic Details
Main Authors: Eykelenboom, Jennifer E., Briggs, Gareth J., Bradshaw, Nicholas J., Soares, Dinesh C., Ogawa, Fumiaki, Christie, Sheila, Malavasi, Elise L.V., Makedonopoulou, Paraskevi, Mackie, Shaun, Malloy, Mary P., Wear, Martin A., Blackburn, Elizabeth A., Bramham, Janice, McIntosh, Andrew M., Blackwood, Douglas H., Muir, Walter J., Porteous, David J., Millar, J. Kirsty
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392113/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392113/

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