Reduced Na+ and higher K+ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice

Reduced Na+ and higher K+ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice

Brugada syndrome (BrS) is associated with ventricular tachycardia originating particularly in the right ventricle (RV). We explore electrophysiological features predisposing to such arrhythmic tendency and their possible RV localization in a heterozygotic Scn5a+/− murine model. Nav1.5 mRNA and prote...

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Bibliographic Details
Main Authors: Martin, Claire A., Siedlecka, Urszula, Kemmerich, Kristin, Lawrence, Jason, Cartledge, James, Guzadhur, Laila, Brice, Nicola, Grace, Andrew A., Schwiening, Christof, Terracciano, Cesare M., Huang, Christopher L.-H.
Format: Online
Language:English
Published: The Royal Society 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390792/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390792/

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