Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene

Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the most common rescue medications used for the treatment of asthma. BDR also serv...

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Main Authors: Himes, Blanca E., Jiang, Xiaofeng, Hu, Ruoxi, Wu, Ann C., Lasky-Su, Jessica A., Klanderman, Barbara J., Ziniti, John, Senter-Sylvia, Jody, Lima, John J., Irvin, Charles G., Peters, Stephen P., Meyers, Deborah A., Bleecker, Eugene R., Kubo, Michiaki, Tamari, Mayumi, Nakamura, Yusuke, Szefler, Stanley J., Lemanske, Robert F., Zeiger, Robert S., Strunk, Robert C., Martinez, Fernando D., Hanrahan, John P., Koppelman, Gerard H., Postma, Dirkje S., Nieuwenhuis, Maartje A. E., Vonk, Judith M., Panettieri, Reynold A., Markezich, Amy, Israel, Elliot, Carey, Vincent J., Tantisira, Kelan G., Litonjua, Augusto A., Lu, Quan, Weiss, Scott T.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390407/