CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

Previous studies have demonstrated that loss of caveolin-1 (Cav-1) in stromal cells drives the activation of the TGF-β signaling, with increased transcription of TGF-β target genes, such as connective tissue growth factor (CTGF). In addition, loss of stromal Cav-1 results in the metabolic reprogramm...

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Bibliographic Details
Main Authors: Capparelli, Claudia, Whitaker-Menezes, Diana, Guido, Carmela, Balliet, Renee, Pestell, Timothy G., Howell, Anthony, Sneddon, Sharon, Pestell, Richard G., Martinez-Outschoorn, Ubaldo, Lisanti, Michael P., Sotgia, Federica
Format: Online
Language:English
Published: Landes Bioscience 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383589/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383589/

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