SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog is strictly regulated by Oct4/Sox2 heter...

Full description

Bibliographic Details
Main Authors: Wu, Yongyan, Guo, Zekun, Wu, Haibo, Wang, Xiaohai, Yang, Lixia, Shi, Xiaoyan, Du, Juan, Tang, Bo, Li, Wenzhong, Yang, Liping, Zhang, Yong
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382131/

Similar Items

Similar Items