Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog
Geminin is an essential cell-cycle protein that is only present from S phase to early mitosis in metazoan somatic cells [1, 2]. Genetic ablation of geminin in the mouse results in preimplantation embryonic lethality because pluripotent cells fail to form and all cells differentiate to trophoblast [3...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083515/ |