Accurate extension of multiple sequence alignments using a phylogeny-aware graph algorithm

Motivation: Accurate alignment of large numbers of sequences is demanding and the computational burden is further increased by downstream analyses depending on these alignments. With the abundance of sequence data, an integrative approach of adding new sequences to existing alignments without their...

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Bibliographic Details
Main Authors: Löytynoja, Ari, Vilella, Albert J., Goldman, Nick
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381962/