Structural organization of brain-derived mammalian prions as probed by hydrogen exchange
One of the mysteries in prion research is the structure of the infectious form of mammalian prion protein, PrPSc. We used MS analysis of H/D exchange to examine brain-derived PrPSc. Our data indicate that, contrary to popular models, prion protein conversion involves refolding of the entire region C...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379881/ |