Recombinant Human Prion Protein Inhibits Prion Propagation in vitro

Recombinant Human Prion Protein Inhibits Prion Propagation in vitro

Prion diseases are associated with the conformational conversion of the cellular prion protein (PrPC) into the pathological scrapie isoform (PrPSc) in the brain. Both the in vivo and in vitro conversion of PrPC into PrPSc is significantly inhibited by differences in amino acid sequence between the t...

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Bibliographic Details
Main Authors: Yuan, Jue, Zhan, Yi-An, Abskharon, Romany, Xiao, Xiangzhu, Martinez, Manuel Camacho, Zhou, Xiaochen, Kneale, Geoff, Mikol, Jacqueline, Lehmann, Sylvain, Surewicz, Witold K., Castilla, Joaquín, Steyaert, Jan, Zhang, Shulin, Kong, Qingzhong, Petersen, Robert B., Wohlkonig, Alexandre, Zou, Wen-Quan
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793212/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793212/

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