A genome-wide association meta-analysis identifies new childhood obesity loci

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made to establish genetic influences on common early-onset obesity. We performed a North American-Australian-European collaborative meta-analysis of fourteen...

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Main Authors:	Bradfield, Jonathan P., Taal, H. Rob, Timpson, Nicholas J., Scherag, André, Lecoeur, Cecile, Warrington, Nicole M., Hypponen, Elina, Holst, Claus, Valcarcel, Beatriz, Thiering, Elisabeth, Salem, Rany M., Schumacher, Fredrick R., Cousminer, Diana L., Sleiman, Patrick M.A., Zhao, Jianhua, Berkowitz, Robert I., Vimaleswaran, Karani S., Jarick, Ivonne, Pennell, Craig E., Evans, David M., St. Pourcain, Beate, Berry, Diane J., Mook-Kanamori, Dennis O, Hofman, Albert, Rivadeinera, Fernando, Uitterlinden, André G., van Duijn, Cornelia M., van der Valk, Ralf J.P., de Jongste, Johan C., Postma, Dirkje S., Boomsma, Dorret I., Gauderman, William J., Hassanein, Mohamed T., Lindgren, Cecilia M., Mägi, Reedik, Boreham, Colin A.G., Neville, Charlotte E., Moreno, Luis A., Elliott, Paul, Pouta, Anneli, Hartikainen, Anna-Liisa, Li, Mingyao, Raitakari, Olli, Lehtimäki, Terho, Eriksson, Johan G., Palotie, Aarno, Dallongeville, Jean, Das, Shikta, Deloukas, Panos, McMahon, George, Ring, Susan M., Kemp, John P., Buxton, Jessica L., Blakemore, Alexandra I.F., Bustamante, Mariona, Guxens, Mònica, Hirschhorn, Joel N., Gillman, Matthew W., Kreiner-Møller, Eskil, Bisgaard, Hans, Gilliland, Frank D., Heinrich, Joachim, Wheeler, Eleanor, Barroso, Inês, O'Rahilly, Stephen, Meirhaeghe, Aline, Sørensen, Thorkild I.A., Power, Chris, Palmer, Lyle J., Hinney, Anke, Widen, Elisabeth, Farooqi, I. Sadaf, McCarthy, Mark I., Froguel, Philippe, Meyre, David, Hebebrand, Johannes, Jarvelin, Marjo-Riitta, Jaddoe, Vincent W.V., Smith, George Davey, Hakonarson, Hakon, Grant, Struan F.A.
Format:	Online
Language:	English
Published:	2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370100/

id	pubmed-3370100
recordtype	oai_dc
spelling	pubmed-33701002012-07-01 A genome-wide association meta-analysis identifies new childhood obesity loci Bradfield, Jonathan P. Taal, H. Rob Timpson, Nicholas J. Scherag, André Lecoeur, Cecile Warrington, Nicole M. Hypponen, Elina Holst, Claus Valcarcel, Beatriz Thiering, Elisabeth Salem, Rany M. Schumacher, Fredrick R. Cousminer, Diana L. Sleiman, Patrick M.A. Zhao, Jianhua Berkowitz, Robert I. Vimaleswaran, Karani S. Jarick, Ivonne Pennell, Craig E. Evans, David M. St. Pourcain, Beate Berry, Diane J. Mook-Kanamori, Dennis O Hofman, Albert Rivadeinera, Fernando Uitterlinden, André G. van Duijn, Cornelia M. van der Valk, Ralf J.P. de Jongste, Johan C. Postma, Dirkje S. Boomsma, Dorret I. Gauderman, William J. Hassanein, Mohamed T. Lindgren, Cecilia M. Mägi, Reedik Boreham, Colin A.G. Neville, Charlotte E. Moreno, Luis A. Elliott, Paul Pouta, Anneli Hartikainen, Anna-Liisa Li, Mingyao Raitakari, Olli Lehtimäki, Terho Eriksson, Johan G. Palotie, Aarno Dallongeville, Jean Das, Shikta Deloukas, Panos McMahon, George Ring, Susan M. Kemp, John P. Buxton, Jessica L. Blakemore, Alexandra I.F. Bustamante, Mariona Guxens, Mònica Hirschhorn, Joel N. Gillman, Matthew W. Kreiner-Møller, Eskil Bisgaard, Hans Gilliland, Frank D. Heinrich, Joachim Wheeler, Eleanor Barroso, Inês O'Rahilly, Stephen Meirhaeghe, Aline Sørensen, Thorkild I.A. Power, Chris Palmer, Lyle J. Hinney, Anke Widen, Elisabeth Farooqi, I. Sadaf McCarthy, Mark I. Froguel, Philippe Meyre, David Hebebrand, Johannes Jarvelin, Marjo-Riitta Jaddoe, Vincent W.V. Smith, George Davey Hakonarson, Hakon Grant, Struan F.A. Article Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made to establish genetic influences on common early-onset obesity. We performed a North American-Australian-European collaborative meta-analysis of fourteen studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight novel signals yielding association with P < 5×10−6 in to nine independent datasets (n = 2,818 cases and 4,083 controls) we observed two loci that yielded a genome wide significant combined P-value, namely near OLFM4 on 13q14 (rs9568856; P=1.82×10−9; OR=1.22) and within HOXB5 on 17q21 (rs9299; P=3.54×10−9; OR=1.14). Both loci continued to show association when including two extreme childhood obesity cohorts (n = 2,214 cases and 2,674 controls). Finally, these two loci yielded directionally consistent associations in the GIANT meta-analysis of adult BMI1. 2012-05 /pmc/articles/PMC3370100/ /pubmed/22484627 http://dx.doi.org/10.1038/ng.2247 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bradfield, Jonathan P. Taal, H. Rob Timpson, Nicholas J. Scherag, André Lecoeur, Cecile Warrington, Nicole M. Hypponen, Elina Holst, Claus Valcarcel, Beatriz Thiering, Elisabeth Salem, Rany M. Schumacher, Fredrick R. Cousminer, Diana L. Sleiman, Patrick M.A. Zhao, Jianhua Berkowitz, Robert I. Vimaleswaran, Karani S. Jarick, Ivonne Pennell, Craig E. Evans, David M. St. Pourcain, Beate Berry, Diane J. Mook-Kanamori, Dennis O Hofman, Albert Rivadeinera, Fernando Uitterlinden, André G. van Duijn, Cornelia M. van der Valk, Ralf J.P. de Jongste, Johan C. Postma, Dirkje S. Boomsma, Dorret I. Gauderman, William J. Hassanein, Mohamed T. Lindgren, Cecilia M. Mägi, Reedik Boreham, Colin A.G. Neville, Charlotte E. Moreno, Luis A. Elliott, Paul Pouta, Anneli Hartikainen, Anna-Liisa Li, Mingyao Raitakari, Olli Lehtimäki, Terho Eriksson, Johan G. Palotie, Aarno Dallongeville, Jean Das, Shikta Deloukas, Panos McMahon, George Ring, Susan M. Kemp, John P. Buxton, Jessica L. Blakemore, Alexandra I.F. Bustamante, Mariona Guxens, Mònica Hirschhorn, Joel N. Gillman, Matthew W. Kreiner-Møller, Eskil Bisgaard, Hans Gilliland, Frank D. Heinrich, Joachim Wheeler, Eleanor Barroso, Inês O'Rahilly, Stephen Meirhaeghe, Aline Sørensen, Thorkild I.A. Power, Chris Palmer, Lyle J. Hinney, Anke Widen, Elisabeth Farooqi, I. Sadaf McCarthy, Mark I. Froguel, Philippe Meyre, David Hebebrand, Johannes Jarvelin, Marjo-Riitta Jaddoe, Vincent W.V. Smith, George Davey Hakonarson, Hakon Grant, Struan F.A.
spellingShingle	Bradfield, Jonathan P. Taal, H. Rob Timpson, Nicholas J. Scherag, André Lecoeur, Cecile Warrington, Nicole M. Hypponen, Elina Holst, Claus Valcarcel, Beatriz Thiering, Elisabeth Salem, Rany M. Schumacher, Fredrick R. Cousminer, Diana L. Sleiman, Patrick M.A. Zhao, Jianhua Berkowitz, Robert I. Vimaleswaran, Karani S. Jarick, Ivonne Pennell, Craig E. Evans, David M. St. Pourcain, Beate Berry, Diane J. Mook-Kanamori, Dennis O Hofman, Albert Rivadeinera, Fernando Uitterlinden, André G. van Duijn, Cornelia M. van der Valk, Ralf J.P. de Jongste, Johan C. Postma, Dirkje S. Boomsma, Dorret I. Gauderman, William J. Hassanein, Mohamed T. Lindgren, Cecilia M. Mägi, Reedik Boreham, Colin A.G. Neville, Charlotte E. Moreno, Luis A. Elliott, Paul Pouta, Anneli Hartikainen, Anna-Liisa Li, Mingyao Raitakari, Olli Lehtimäki, Terho Eriksson, Johan G. Palotie, Aarno Dallongeville, Jean Das, Shikta Deloukas, Panos McMahon, George Ring, Susan M. Kemp, John P. Buxton, Jessica L. Blakemore, Alexandra I.F. Bustamante, Mariona Guxens, Mònica Hirschhorn, Joel N. Gillman, Matthew W. Kreiner-Møller, Eskil Bisgaard, Hans Gilliland, Frank D. Heinrich, Joachim Wheeler, Eleanor Barroso, Inês O'Rahilly, Stephen Meirhaeghe, Aline Sørensen, Thorkild I.A. Power, Chris Palmer, Lyle J. Hinney, Anke Widen, Elisabeth Farooqi, I. Sadaf McCarthy, Mark I. Froguel, Philippe Meyre, David Hebebrand, Johannes Jarvelin, Marjo-Riitta Jaddoe, Vincent W.V. Smith, George Davey Hakonarson, Hakon Grant, Struan F.A. A genome-wide association meta-analysis identifies new childhood obesity loci
author_facet	Bradfield, Jonathan P. Taal, H. Rob Timpson, Nicholas J. Scherag, André Lecoeur, Cecile Warrington, Nicole M. Hypponen, Elina Holst, Claus Valcarcel, Beatriz Thiering, Elisabeth Salem, Rany M. Schumacher, Fredrick R. Cousminer, Diana L. Sleiman, Patrick M.A. Zhao, Jianhua Berkowitz, Robert I. Vimaleswaran, Karani S. Jarick, Ivonne Pennell, Craig E. Evans, David M. St. Pourcain, Beate Berry, Diane J. Mook-Kanamori, Dennis O Hofman, Albert Rivadeinera, Fernando Uitterlinden, André G. van Duijn, Cornelia M. van der Valk, Ralf J.P. de Jongste, Johan C. Postma, Dirkje S. Boomsma, Dorret I. Gauderman, William J. Hassanein, Mohamed T. Lindgren, Cecilia M. Mägi, Reedik Boreham, Colin A.G. Neville, Charlotte E. Moreno, Luis A. Elliott, Paul Pouta, Anneli Hartikainen, Anna-Liisa Li, Mingyao Raitakari, Olli Lehtimäki, Terho Eriksson, Johan G. Palotie, Aarno Dallongeville, Jean Das, Shikta Deloukas, Panos McMahon, George Ring, Susan M. Kemp, John P. Buxton, Jessica L. Blakemore, Alexandra I.F. Bustamante, Mariona Guxens, Mònica Hirschhorn, Joel N. Gillman, Matthew W. Kreiner-Møller, Eskil Bisgaard, Hans Gilliland, Frank D. Heinrich, Joachim Wheeler, Eleanor Barroso, Inês O'Rahilly, Stephen Meirhaeghe, Aline Sørensen, Thorkild I.A. Power, Chris Palmer, Lyle J. Hinney, Anke Widen, Elisabeth Farooqi, I. Sadaf McCarthy, Mark I. Froguel, Philippe Meyre, David Hebebrand, Johannes Jarvelin, Marjo-Riitta Jaddoe, Vincent W.V. Smith, George Davey Hakonarson, Hakon Grant, Struan F.A.
author_sort	Bradfield, Jonathan P.
title	A genome-wide association meta-analysis identifies new childhood obesity loci
title_short	A genome-wide association meta-analysis identifies new childhood obesity loci
title_full	A genome-wide association meta-analysis identifies new childhood obesity loci
title_fullStr	A genome-wide association meta-analysis identifies new childhood obesity loci
title_full_unstemmed	A genome-wide association meta-analysis identifies new childhood obesity loci
title_sort	genome-wide association meta-analysis identifies new childhood obesity loci
description	Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made to establish genetic influences on common early-onset obesity. We performed a North American-Australian-European collaborative meta-analysis of fourteen studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight novel signals yielding association with P < 5×10−6 in to nine independent datasets (n = 2,818 cases and 4,083 controls) we observed two loci that yielded a genome wide significant combined P-value, namely near OLFM4 on 13q14 (rs9568856; P=1.82×10−9; OR=1.22) and within HOXB5 on 17q21 (rs9299; P=3.54×10−9; OR=1.14). Both loci continued to show association when including two extreme childhood obesity cohorts (n = 2,214 cases and 2,674 controls). Finally, these two loci yielded directionally consistent associations in the GIANT meta-analysis of adult BMI1.
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370100/
_version_	1611535381410349056

A genome-wide association meta-analysis identifies new childhood obesity loci

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