Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease

Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease

In Alzheimer disease (AD) patient brains, the accumulation of amyloid-β (Aβ) peptides is associated with activated microglia. Aβ is derived from the amyloid precursor protein; two major forms of Aβ, that is, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), exist. We previously reported that rat microglia phagocytos...

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Bibliographic Details
Main Authors: Takata, Kazuyuki, Takada, Tetsuya, Ito, Aina, Asai, Mayo, Tawa, Manami, Saito, Yuki, Ashihara, Eishi, Tomimoto, Hidekazu, Kitamura, Yoshihisa, Shimohama, Shun
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357001/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357001/

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