Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS

Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS

A novel formulation containing polyvinylpyrrolidone (PVP) K30-coated norcantharidin (NCTD) chitosan nanoparticles (PVP–NCTD–NPs) was prepared by ionic gelation between chitosan and sodium tripolyphosphate. The average particle size of the PVP–NCTD–NPs produced was 140.03 ± 6.23 nm; entrapment effici...

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Bibliographic Details
Main Authors: Ding, Xin-Yuan, Hong, Cheng-Jiao, Liu, Yang, Gu, Zong-Lin, Xing, Kong-Lang, Zhu, Ai-Jun, Chen, Wei-Liang, Shi, Lin-Seng, Zhang, Xue-Nong, Zhang, Qiang
Format: Online
Language:English
Published: Dove Medical Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356170/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356170/

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