Largazole Pharmacokinetics in Rats by LC-MS/MS

Largazole Pharmacokinetics in Rats by LC-MS/MS

A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated. Largazole thiol was extracted with ethyl acetate from human or rat plasma alo...

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Bibliographic Details
Main Authors: Yu, Mingming, Salvador, Lilibeth A., Sy, Sherwin K. B., Tang, Yufei, Singh, Ravi S. P., Chen, Qi-Yin, Liu, Yanxia, Hong, Jiyong, Derendorf, Hartmut, Luesch, Hendrik
Format: Online
Language:English
Published: MDPI 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967229/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967229/

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