An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins

An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins

Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (±) BI97D6. We report here the synthesis and evaluation on its optically pure (−...

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Bibliographic Details
Main Authors: Wei, Jun, Stebbins, John L., Kitada, Shinichi, Dash, Rupesh, Zhai, Dayong, Placzek, William J., Wu, Bainan, Rega, Michele F., Zhang, Ziming, Barile, Elisa, Yang, Li, Dahl, Russell, Fisher, Paul B., Reed, John C., Pellecchia, Maurizio
Format: Online
Language:English
Published: Frontiers Research Foundation 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356046/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356046/

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