Identification of a Rare 3 bp BRAF Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction

Identification of a Rare 3 bp BRAF Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction

Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, and 36-69% of PTC cases are caused by mutations in the BRAF gene. The substitution of a valine for a glutamic acid (V600E) comprises up to 95-100% of BRAF mutations; therefore, most diagnostic methods, including allele-spe...

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Bibliographic Details
Main Authors: Jang, Mi-Ae, Lee, Seung-Tae, Oh, Young Lyun, Kim, Sun Wook, Chung, Jae Hoon, Ki, Chang-Seok, Kim, Jong-Won
Format: Online
Language:English
Published: The Korean Society for Laboratory Medicine 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339308/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339308/

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