Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration
The role of inflammation in the progression of neurodegenerative disease remains unclear. We have shown that systemic bacterial insults accelerate disease progression in animals and in patients with Alzheimer’s disease. Disease exacerbation is associated with exaggerated CNS inflammatory responses t...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Academic Press
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334265/ |