Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

Type I IFN signaling is indispensable for the maturation of dendritic cells (DCs) that are required to elicit an immune response, and it also controls a shift in cellular metabolism to meet the increased energy demands of DC maturation.

Bibliographic Details
Main Authors: Pantel, Austin, Teixeira, Angela, Haddad, Elias, Wood, Elizabeth G., Steinman, Ralph M., Longhi, M. Paula
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883643/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883643/

Similar Items