Prion Protein Misfolding
The crucial event in the development of transmissible spongiform encephalopathies (TSEs) is the conformational change of a host-encoded membrane protein - the cellular PrPC - into a disease associated, fibril-forming isoform PrPSc. This conformational transition from the α-helix-rich cellular form i...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Bentham Science Publishers Ltd.
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330701/ |