Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells

Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP), routinely administered at the age of 65, has limited effectiveness, and revaccination induces attenuated antibody responses. It is not known whether pneumococcal polysaccharide-protein conjugated vaccines (PCV), althoug...

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Main Authors:	Clutterbuck, Elizabeth A., Lazarus, Rajeka, Yu, Ly-Mee, Bowman, Jaclyn, Bateman, Elizabeth A. L., Diggle, Linda, Angus, Brian, Peto, Tim E., Beverley, Peter C., Mant, David, Pollard, Andrew J.
Format:	Online
Language:	English
Published:	Oxford University Press 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324398/

id	pubmed-3324398
recordtype	oai_dc
spelling	pubmed-33243982012-04-12 Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells Clutterbuck, Elizabeth A. Lazarus, Rajeka Yu, Ly-Mee Bowman, Jaclyn Bateman, Elizabeth A. L. Diggle, Linda Angus, Brian Peto, Tim E. Beverley, Peter C. Mant, David Pollard, Andrew J. Major Articles and Brief Reports Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP), routinely administered at the age of 65, has limited effectiveness, and revaccination induces attenuated antibody responses. It is not known whether pneumococcal polysaccharide-protein conjugated vaccines (PCV), although highly effective in infants, offer any immunological advantages over 23vP in adults. Oxford University Press 2012-05-01 2012-03-28 /pmc/articles/PMC3324398/ /pubmed/22457293 http://dx.doi.org/10.1093/infdis/jis212 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Clutterbuck, Elizabeth A. Lazarus, Rajeka Yu, Ly-Mee Bowman, Jaclyn Bateman, Elizabeth A. L. Diggle, Linda Angus, Brian Peto, Tim E. Beverley, Peter C. Mant, David Pollard, Andrew J.
spellingShingle	Clutterbuck, Elizabeth A. Lazarus, Rajeka Yu, Ly-Mee Bowman, Jaclyn Bateman, Elizabeth A. L. Diggle, Linda Angus, Brian Peto, Tim E. Beverley, Peter C. Mant, David Pollard, Andrew J. Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells
author_facet	Clutterbuck, Elizabeth A. Lazarus, Rajeka Yu, Ly-Mee Bowman, Jaclyn Bateman, Elizabeth A. L. Diggle, Linda Angus, Brian Peto, Tim E. Beverley, Peter C. Mant, David Pollard, Andrew J.
author_sort	Clutterbuck, Elizabeth A.
title	Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells
title_short	Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells
title_full	Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells
title_fullStr	Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells
title_full_unstemmed	Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells
title_sort	pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific b cells
description	Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP), routinely administered at the age of 65, has limited effectiveness, and revaccination induces attenuated antibody responses. It is not known whether pneumococcal polysaccharide-protein conjugated vaccines (PCV), although highly effective in infants, offer any immunological advantages over 23vP in adults.
publisher	Oxford University Press
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324398/
_version_	1611520429032210432

Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells

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