Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain

Duplications and triplications of the α-synuclein (SNCA) gene increase risk for PD, suggesting increased expression levels of the gene to be associated with increased PD risk. However, past SNCA expression studies in brain tissue report inconsistent results. We examined expression of the full-length...

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Main Authors:	Dumitriu, Alexandra, Moser, Carlee, Hadzi, Tiffany C., Williamson, Sally L., Pacheco, Christopher D., Hendricks, Audrey E., Latourelle, Jeanne C., Wilk, Jemma B., DeStefano, Anita L., Myers, Richard H.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317023/

id	pubmed-3317023
recordtype	oai_dc
spelling	pubmed-33170232012-04-23 Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain Dumitriu, Alexandra Moser, Carlee Hadzi, Tiffany C. Williamson, Sally L. Pacheco, Christopher D. Hendricks, Audrey E. Latourelle, Jeanne C. Wilk, Jemma B. DeStefano, Anita L. Myers, Richard H. Research Article Duplications and triplications of the α-synuclein (SNCA) gene increase risk for PD, suggesting increased expression levels of the gene to be associated with increased PD risk. However, past SNCA expression studies in brain tissue report inconsistent results. We examined expression of the full-length SNCA transcript (140 amino acid protein isoform), as well as total SNCA mRNA levels in 165 frontal cortex samples (101 PD, 64 control) using quantitative real-time polymerase chain reaction. Additionally, we evaluated the relationship of eight SNPs in both 5′ and 3′ regions of SNCA with the gene expression levels. The association between postmortem interval (PMI) and SNCA expression was different for PD and control samples: SNCA expression decreased with increasing PMI in cases, while staying relatively constant in controls. For short PMI, SNCA expression was increased in PD relative to control samples, whereas for long PMI, SNCA expression in PD was decreased relative to control samples. Hindawi Publishing Corporation 2012 2012-03-13 /pmc/articles/PMC3317023/ /pubmed/22530163 http://dx.doi.org/10.1155/2012/614212 Text en Copyright © 2012 Alexandra Dumitriu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Dumitriu, Alexandra Moser, Carlee Hadzi, Tiffany C. Williamson, Sally L. Pacheco, Christopher D. Hendricks, Audrey E. Latourelle, Jeanne C. Wilk, Jemma B. DeStefano, Anita L. Myers, Richard H.
spellingShingle	Dumitriu, Alexandra Moser, Carlee Hadzi, Tiffany C. Williamson, Sally L. Pacheco, Christopher D. Hendricks, Audrey E. Latourelle, Jeanne C. Wilk, Jemma B. DeStefano, Anita L. Myers, Richard H. Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
author_facet	Dumitriu, Alexandra Moser, Carlee Hadzi, Tiffany C. Williamson, Sally L. Pacheco, Christopher D. Hendricks, Audrey E. Latourelle, Jeanne C. Wilk, Jemma B. DeStefano, Anita L. Myers, Richard H.
author_sort	Dumitriu, Alexandra
title	Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
title_short	Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
title_full	Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
title_fullStr	Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
title_full_unstemmed	Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
title_sort	postmortem interval influences α-synuclein expression in parkinson disease brain
description	Duplications and triplications of the α-synuclein (SNCA) gene increase risk for PD, suggesting increased expression levels of the gene to be associated with increased PD risk. However, past SNCA expression studies in brain tissue report inconsistent results. We examined expression of the full-length SNCA transcript (140 amino acid protein isoform), as well as total SNCA mRNA levels in 165 frontal cortex samples (101 PD, 64 control) using quantitative real-time polymerase chain reaction. Additionally, we evaluated the relationship of eight SNPs in both 5′ and 3′ regions of SNCA with the gene expression levels. The association between postmortem interval (PMI) and SNCA expression was different for PD and control samples: SNCA expression decreased with increasing PMI in cases, while staying relatively constant in controls. For short PMI, SNCA expression was increased in PD relative to control samples, whereas for long PMI, SNCA expression in PD was decreased relative to control samples.
publisher	Hindawi Publishing Corporation
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317023/
_version_	1611518339052470272

Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain

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