Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL*

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL*

Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ligands can trigger the formation of nonproductive receptor complexes, which slows...

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Bibliographic Details
Main Authors: Szegezdi, Eva, van der Sloot, Almer M., Mahalingam, Devalingam, O'Leary, Lynda, Cool, Robbert H., Muñoz, Inés G., Montoya, Guillermo, Quax, Wim J., de Jong, Steven, Samali, Afshin, Serrano, Luis
Format: Online
Language:English
Published: The American Society for Biochemistry and Molecular Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316727/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316727/

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