Cancer's sweet tooth for serine
Exemplified by the cancer cell's preference for glycolysis (the Warburg effect), altered metabolism has taken centerstage as an emerging hallmark of cancer. Charting the landscape of cancer metabolic addictions should reveal new avenues for therapeutic attack. Two recent studies found subsets o...
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| Format: | Online |
| Language: | English |
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BioMed Central
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315682/ |
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pubmed-3315682 |
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pubmed-33156822012-05-28 Cancer's sweet tooth for serine Luo, Ji Viewpoint Exemplified by the cancer cell's preference for glycolysis (the Warburg effect), altered metabolism has taken centerstage as an emerging hallmark of cancer. Charting the landscape of cancer metabolic addictions should reveal new avenues for therapeutic attack. Two recent studies found subsets of human melanoma and breast cancers to have high levels of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine biosynthesis, and these cancer cells are dependent on PHGDH for their growth and survival. Tumors may thus harbor distinct metabolic alterations to support their malignancy, and targeting enzymes such as PHGDH might prove a viable therapeutic strategy in this scenario. BioMed Central 2011 2011-11-28 /pmc/articles/PMC3315682/ /pubmed/22189202 http://dx.doi.org/10.1186/bcr2932 Text en Copyright ©2010 BioMed Central Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Luo, Ji |
| spellingShingle |
Luo, Ji Cancer's sweet tooth for serine |
| author_facet |
Luo, Ji |
| author_sort |
Luo, Ji |
| title |
Cancer's sweet tooth for serine |
| title_short |
Cancer's sweet tooth for serine |
| title_full |
Cancer's sweet tooth for serine |
| title_fullStr |
Cancer's sweet tooth for serine |
| title_full_unstemmed |
Cancer's sweet tooth for serine |
| title_sort |
cancer's sweet tooth for serine |
| description |
Exemplified by the cancer cell's preference for glycolysis (the Warburg effect), altered metabolism has taken centerstage as an emerging hallmark of cancer. Charting the landscape of cancer metabolic addictions should reveal new avenues for therapeutic attack. Two recent studies found subsets of human melanoma and breast cancers to have high levels of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine biosynthesis, and these cancer cells are dependent on PHGDH for their growth and survival. Tumors may thus harbor distinct metabolic alterations to support their malignancy, and targeting enzymes such as PHGDH might prove a viable therapeutic strategy in this scenario. |
| publisher |
BioMed Central |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315682/ |
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1611517774460354560 |