Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein

The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR. Depletion of EspR reportedly affects a small number of genes, both positively or negatively, including a key ESX-1 component, th...

Full description

Bibliographic Details
Main Authors: Blasco, Benjamin, Chen, Jeffrey M., Hartkoorn, Ruben, Sala, Claudia, Uplekar, Swapna, Rougemont, Jacques, Pojer, Florence, Cole, Stewart T.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315491/