Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice

Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice

The Bcl-2 regulated apoptosis pathway is critical for the elimination of autoreactive lymphocytes, thereby precluding autoimmunity. T cells escaping this process can be kept in check by regulatory T (Treg) cells expressing the transcription and lineage commitment factor Foxp3. Despite the well-estab...

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Bibliographic Details
Main Authors: Tischner, Denise, Gaggl, Irene, Peschel, Ines, Kaufmann, Manuel, Tuzlak, Selma, Drach, Mathias, Thuille, Nikolaus, Villunger, Andreas, Jan Wiegers, G.
Format: Online
Language:English
Published: Academic Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314992/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314992/

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