T-bet represses expression of PD-1 and sustains virus-specific CD8 T cell responses during chronic infection

T-bet represses expression of PD-1 and sustains virus-specific CD8 T cell responses during chronic infection

T cell exhaustion plays a major role in failure to control chronic infections. High expression of inhibitory receptors, including PD-1, and the inability to sustain functional T cell responses contribute to exhaustion. However, the transcriptional control of these processes remains unclear. Here we...

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Bibliographic Details
Main Authors: Kao, Charlly, Oestreich, Kenneth J., Paley, Michael A., Crawford, Alison, Angelosanto, Jill M., Ali, Mohammed-Alkhatim A., Intlekofer, Andrew M., Boss, Jeremy M., Reiner, Steven L., Weinmann, Amy S., Wherry, E. John
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306165/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306165/

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