Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile
T-bet and Bcl-6 are required to establish TH1 or TFH gene expression profiles, respectively. Here, we demonstrated that high interleukin 2 (IL-2) concentrations inhibited Bcl-6 expression in polarized TH1 cells. Mechanistically, the low amounts of Bcl-6 normally found in effector TH1 cells could not...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561768/ |