Differential confounding of rare and common variants in spatially structured populations

Well-powered genome-wide association studies, now possible through advances in technology and large-scale collaborative projects, promise to reveal the contribution of rare variants to complex traits and disease. However, while population structure is a known confounder of association studies, it is...

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Bibliographic Details
Main Authors: Mathieson, Iain, McVean, Gil
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303124/