Growth of Novel Epistatic Interactions by Gene Duplication
Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Gene duplication is a major mechanism of evolution for genetic novelties. Here, we demonstrate that genes evolved significantly more epistatic inte...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Oxford University Press
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274824/ |
| id |
pubmed-3274824 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-32748242012-02-08 Growth of Novel Epistatic Interactions by Gene Duplication Jiang, Huifeng Xu, Lin Gu, Zhenglong Research Articles Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Gene duplication is a major mechanism of evolution for genetic novelties. Here, we demonstrate that genes evolved significantly more epistatic interactions after duplication. The connectivity of duplicate gene pairs in epistatic networks is positively correlated with the extent of their sequence divergence. Furthermore, duplicate gene pairs tend to epistatically interact with genes that occupy more functional spaces than do single-copy genes. These results show that gene duplication plays an important role in the evolution of epistasis. Oxford University Press 2011-03-14 /pmc/articles/PMC3274824/ /pubmed/21402864 http://dx.doi.org/10.1093/gbe/evr016 Text en The Author(s) 2011. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jiang, Huifeng Xu, Lin Gu, Zhenglong |
| spellingShingle |
Jiang, Huifeng Xu, Lin Gu, Zhenglong Growth of Novel Epistatic Interactions by Gene Duplication |
| author_facet |
Jiang, Huifeng Xu, Lin Gu, Zhenglong |
| author_sort |
Jiang, Huifeng |
| title |
Growth of Novel Epistatic Interactions by Gene Duplication |
| title_short |
Growth of Novel Epistatic Interactions by Gene Duplication |
| title_full |
Growth of Novel Epistatic Interactions by Gene Duplication |
| title_fullStr |
Growth of Novel Epistatic Interactions by Gene Duplication |
| title_full_unstemmed |
Growth of Novel Epistatic Interactions by Gene Duplication |
| title_sort |
growth of novel epistatic interactions by gene duplication |
| description |
Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Gene duplication is a major mechanism of evolution for genetic novelties. Here, we demonstrate that genes evolved significantly more epistatic interactions after duplication. The connectivity of duplicate gene pairs in epistatic networks is positively correlated with the extent of their sequence divergence. Furthermore, duplicate gene pairs tend to epistatically interact with genes that occupy more functional spaces than do single-copy genes. These results show that gene duplication plays an important role in the evolution of epistasis. |
| publisher |
Oxford University Press |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274824/ |
| _version_ |
1611504584710160384 |