InsR/FoxO1 Signaling Curtails Hypothalamic POMC Neuron Number

Insulin receptor (InsR) signaling through transcription factor FoxO1 is important in the development of hypothalamic neuron feeding circuits, but knowledge about underlying mechanisms is limited. To investigate the role of InsR/FoxO1 signaling in the development and maintenance of these circuits, we...

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Bibliographic Details
Main Authors: Plum, Leona, Lin, Hua V., Aizawa, Kumiko S., Liu, Yitian, Accili, Domenico
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271107/