Asc Modulates the Function of NLRC4 in Response to Infection of Macrophages by Legionella pneumophila
Nucleotide-binding domain, leucine-rich repeat containing proteins (NLRs) activate caspase-1 in response to a variety of bacterium-derived signals in macrophages. NLR-mediated activation of caspase-1 by Legionella pneumophila occurs through both an NLRC4/NAIP5-dependent pathway and a pathway requiri...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
American Society of Microbiology
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269931/ |