Evaluating the conformation of recombinant domain I of β2-glycoprotein I and its interaction with human monoclonal antibodies

Evaluating the conformation of recombinant domain I of β2-glycoprotein I and its interaction with human monoclonal antibodies

► Bacterial expressed human recombinant DI has a structure consistent with that of DI in the published β2GPI crystal structure. ► Mutating residues D8/D9 and R39 do not alter the overall DI protein fold but cause local changes in surface contour. ► Monoclonal aPL-derived antibodies and DI of β2GPI i...

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Bibliographic Details
Main Authors: Pericleous, Charis, Miles, Jennifer, Esposito, Diego, Garza-Garcia, Acely, Driscoll, Paul C., Lambrianides, Anastasia, Latchman, David, Isenberg, David, Rahman, Anisur, Ioannou, Yiannis, Giles, Ian
Format: Online
Language:English
Published: Pergamon Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268385/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268385/

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