Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity

Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity

Bibliographic Details
Main Authors:	Kakinohana, Osamu, Hefferan, Michael P., Miyanohara, Atsushi, Nejime, Tetsuya, Marsala, Silvia, Juhas, Stefan, Juhasova, Jana, Motlik, Jan, Kucharova, Karolina, Strnadel, Jan, Platoshyn, Oleksandr, Lazar, Peter, Galik, Jan, Vinay, Laurent, Marsala, Martin
Format:	Online
Language:	English
Published:	Public Library of Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264568/

Similar Items

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation
by: van Gorp, Sebastiaan, et al.
Published: (2013)

Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation
by: Hefferan, Michael P., et al.
Published: (2012)

Thoracic 9 Spinal Transection-Induced Model of Muscle Spasticity in the Rat: A Systematic Electrophysiological and Histopathological Characterization
by: Corleto, Jose A., et al.
Published: (2015)

Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the Meninges and the Choroid Plexus: Implications for Non-Neuronal Sources for GABA in the Developing Mouse Brain
by: Tochitani, Shiro, et al.
Published: (2013)

Decline in Titers of Anti-Idiotypic Antibodies Specific to Autoantibodies to GAD65 (GAD65Ab) Precedes Development of GAD65Ab and Type 1 Diabetes
by: Larsson, Helena Elding, et al.
Published: (2013)

In Vivo Gene Knockdown in Rat Dorsal Root Ganglia Mediated by Self-Complementary Adeno-Associated Virus Serotype 5 Following Intrathecal Delivery
by: Xu, Qinghao, et al.
Published: (2012)

An Analysis of the Cross-Reactivity of Autoantibodies to GAD65 and GAD67 in Diabetes
by: Jayakrishnan, Bindu, et al.
Published: (2011)

Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs
by: Miyanohara, Atsushi, et al.
Published: (2016)

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome
by: Gu Urban, Gucci Jijuan, et al.
Published: (2015)

Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain
by: Kami, Katsuya, et al.
Published: (2016)

Assessment of CD4+ T Cell Responses to Glutamic Acid Decarboxylase 65 Using DQ8 Tetramers Reveals a Pathogenic Role of GAD65 121–140 and GAD65 250–266 in T1D Development
by: Chow, I-Ting, et al.
Published: (2014)

Epigenetic suppression of GAD65 expression mediates persistent pain
by: Zhang, Zhi, et al.
Published: (2011)

Improvement of GAD65-associated autoimmune epilepsy with testosterone replacement therapy
by: Heiry, Melissa, et al.
Published: (2015)

Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission
by: Hackert, Jana K., et al.
Published: (2016)

No evidence of antibodies against GAD65 and other specific antigens in children with autism
by: Kalra, Simran, et al.
Published: (2015)

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
by: McGinty, John W., et al.
Published: (2014)

GAD65 haplodeficiency conveys resilience in animal models of stress-induced psychopathology
by: Müller, Iris, et al.
Published: (2014)

Single loop-and-clips technique (KING closure) for gastrotomy closure after transgastric ovariectomy: a survival experiment
by: Ryska, Ondrej, et al.
Published: (2012)

Hypercapnic ventilatory response in mice lacking the 65 kDa isoform of Glutamic Acid Decarboxylase (GAD65)
by: Bissonnette, John M, et al.
Published: (2004)

Subdural hematoma presenting as trigeminal neuralgia: A case report
by: Marsala, Sandro Zambito, et al.
Published: (2016)

Utilization of Advanced Methods in the Control of a Mechatronic System with Flexible Elements
by: Juhás Martin, et al.
Published: (2016-12-01)

Design of a Communication Scheme in a Modern Factory in Accordance with the Standard of Industry 4.0
by: Halenár Igor, et al.
Published: (2016-12-01)

Substrate Selectivity of the Acid-activated Glutamate/γ-Aminobutyric acid (GABA) Antiporter GadC from Escherichia coli*
by: Ma, Dan, et al.
Published: (2013)

Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model
by: Subburaju, S, et al.
Published: (2016)

Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons
by: Kanaani, Jamil, et al.
Published: (2015)

Obturator neurolysis using 65% alcohol for adductor muscle spasticity
by: Ghai, Anju, et al.
Published: (2012)

Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain
Published: (1992)

A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65
by: Kanaani, Jamil, et al.
Published: (2002)

A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region
Published: (1994)

Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome
Published: (1993)

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
Published: (1996)

Anti-Idiotypic Antibody Specific to GAD65 Autoantibody Prevents Type 1 Diabetes in the NOD Mouse
by: Wang, Xin, et al.
Published: (2012)

GAD65 Positive Autoimmune Limbic Encephalitis: A Case Report and Review of Literature
by: Sharma, Abhishek, et al.
Published: (2012)

Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model
by: Zheng, Deyu, et al.
Published: (2013)

GAD65 Autoantibodies Detected by Electrochemiluminescence Assay Identify High Risk for Type 1 Diabetes
by: Miao, Dongmei, et al.
Published: (2013)

Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment
by: Singh, Sandeep, et al.
Published: (2012)

Ascending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding
by: García-Peña, Claudia M., et al.
Published: (2014)

Treating a GAD65 Antibody-Associated Limbic Encephalitis with Basiliximab: A Case Study
by: Widman, Guido, et al.
Published: (2015)

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity
by: Phelps, Edward A., et al.
Published: (2016)

Oral Administration of Silkworm-Produced GAD65 and Insulin Bi-Autoantigens against Type 1 Diabetes
by: Liu, Baoping, et al.
Published: (2016)