Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

Removal of the fucose residue from the N-glycans of the Fc portion of immunoglobulin G (IgG) results in a dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC) through improved affinity for Fcγ receptor IIIa (FcγRIIIa). Here, we present the 2.2-Å structure of the complex formed bet...

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Bibliographic Details
Main Authors: Mizushima, Tsunehiro, Yagi, Hirokazu, Takemoto, Emi, Shibata-Koyama, Mami, Isoda, Yuya, Iida, Shigeru, Masuda, Kazuhiro, Satoh, Mitsuo, Kato, Koichi
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258418/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258418/

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