Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes

Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes

TNFα stimulates both pro- and anti-apoptotic signalling in hepatocytes. Anti-apoptotic signalling depends on a cascade of ubiquitylation steps leading to NFκB activation. Using Sharpin-deficient mice, we show that the ubiquitin binding protein Sharpin interacts with Hoip, an E3 ligase which generate...

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Bibliographic Details
Main Authors: Sieber, Sabrina, Lange, Nicole, Kollmorgen, Gwendlyn, Erhardt, Annette, Quaas, Alexander, Gontarewicz, Arthur, Sass, Gabriele, Tiegs, Gisa, Kreienkamp, Hans-Jürgen
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253811/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253811/

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