Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly complex (LUBAC). However, it is currently unclear how regulat...

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Bibliographic Details
Main Authors: De Franceschi, Nicola, Peuhu, Emilia, Parsons, Maddy, Rissanen, Sami, Vattulainen, Ilpo, Salmi, Marko, Ivaska, Johanna, Pouwels, Jeroen
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658161/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658161/

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